Stem Cell Growth Factors and Baldness

There was a very interesting news item in field of hair transplant which I would like to share. This concerns cause of male pattern alopecia.
It is a known fact that in male pattern balding (Androgenetic alopecia), hair follicles don't disappear. They become so small by a process called “miniaturization” that they are not visible to naked eye. Although, we know that DHT is responsible for this process, how exactly it causes miniaturization of hair roots is still not known.

One theory of miniaturization says that DHT causes stem cell depletion in hair follicles of bald areas. A new study, published in the Journal of Clinical Investigation, tries to shed some light on this.  The research team led by Dr. Costarelis, MD collected cell samples from bald and non bald areas from the same persons and counted the number of stem cells present. They were surprised to find that bald areas had the same number of stem cells as hair bearing areas. When they looked further, they found that another cell type, which develops from stem cell, called progenitor cell was deficient in miniaturized follicle.

Dr Costarelis says that, "This implies that there is a problem in the activation of stem cells converting to progenitor cells in bald scalp." As of now, why or what causes the arrest in progression of stem cells to progenitor cells is not known. "However, the fact that there are normal numbers of stem cells in bald scalp gives us hope for reactivating those stem cells," notes Costarelis.
The logical next step would be to identify the factors that arrest this progression and to remove them. A locally applied agent or growth factors that can help stem cells to get converted to progenitor cells would also be very useful.
I have used growth factors injections in some of my patients. The results, especially when used with PRP are good but temporary. The repeated injections overcome the cost benefit. The big break will be an agent that can grow hair permanently. Till then we have hair transplants.

Top 5 Hair Loss Myths

When you are suffering from hair loss, every one will offer you an advice or two. From office boy to neighborhood auntie, each can tell you cause and remedy of your hair loss. How they became so knowledgeable is anybody’s guess but here is a list to tell you when they are right and when they are not.

Myth No.1 : Shaving the Head will Prevent Hair Loss

NO! NO! NO! Shaving does not prevent hair fall. Probably the origin of this myth lies in the fact that short stubble feels coarser and is therefore considered made of better quality hair. In fact, it only feels harder because the hair is short and not because hair quality has improved overnight.  

Another contributing factor to the popularity of this myth may be that you stop “seeing” hair loss. After shaving your head, you don’t see hair in your hands or pillow like you used to. This is again because the hair is so short that you don’t notice its fall and not because hair loss has stopped.

Remember, the hair is falling due to hair root injury and shaving can not change this process. Hair fall will continue even if you shave your head hundred times.

Myth No.2 :  Dandruff causes Hair Loss

Again not true. The origin of this myth is the fact that every time you scratch your scalp you get one or two hair in your hands. These are just weak telogen hair that were about to fall any way. Dandruff on the other hand is a surface infection or colonization by a fungus. It happens in oily scalp and is medically treatable. It does not cause any damage to hair roots. Also remember that flaking of dry scalp is different from dandruff and only requires good hair conditioner.

Myth No.3 : Tension causes Hair Loss

False.  I  don’t know where this came from. Severe prolonged stress due to injury or disease can cause telogen effluvium, but day to day stress does not exacerbate hair loss.

Myth No.4 : Helmet or Hat causes Hair Loss

Wrong. Tight helmets or hats may contribute to hair fiber damage, but it does not cause root injury. On the other hand, pulling the hair too hard while wearing a turban or cornrows, can cause permanent hair loss. This is called traction alopecia and requires surgical treatment.

Myth No.5 : Oiling Prevents Hair Loss

Not true. Adequate oil is produced by your scalp to nourish hair roots. In fact, evey hair has its own oil producing gland. If you have very long hair, then putting hair oils may improve the texture, but short hairs do not require oiling. Head massage with oils can relax you but does little for hair growth.

So, what causes hair loss? I shall discuss this in my next blog.